Set in the weeks following Resistance: Fall of Man, Resistance: Retribution follows the story of former British Marine James Grayson.
After a personal tragedy, he is forced to kill his own brother inside a Chimeran conversion center. Grayson embarks on a vendetta to destroy any conversion centers he can find.
Eventually, Grayson learns that his efforts were in vain. In Western Europe, the Chimeras have developed a new method of converting humans into aliens.
The European resistance—the Maquis—request Grayson's help, and he joins Cartwright and Parker in Operation Overstrike.
The war to retake the European continent has begun.