After joining a new unit of the BSAA (Bioterrorism Security Assessment Alliance), Chris Redfield, who we finally meet again in this episode, is sent to Africa to a small village called Kitjutsu (Kijuju).
Following recent bioterrorist acts that occurred in 2008, the inhabitants and animals of this village have been transformed into ferocious, sentient creatures.
Chris will have to uncover the truth to foil an evil plot.
With the help of his partner Sheva Alomar, he must also confront the protagonists responsible for these incidents, who are none other than his lifelong enemy... the terrible Albert Wesker, assisted this time by the mysterious Excella Gionne.